196302-91-7

Basic information

• Product Name: D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,5,6-tris-O-(phenylmethyl)-3,4-O-(1S,2R,4S)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-
• Synonyms: D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,5,6-tris-O-(phenylmethyl)-3,4-O-(1S,2R,4S)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-
• CAS NO: 196302-91-7
• Molecular Formula: C₄₅H₅₂O₇
• Molecular Weight: 704.89
• Mol File: 196302-91-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,5,6-tris-O-(phenylmethyl)-3,4-O-(1S,2R,4S)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-(CAS DataBase Reference)
• NIST Chemistry Reference: D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,5,6-tris-O-(phenylmethyl)-3,4-O-(1S,2R,4S)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-(196302-91-7)
• EPA Substance Registry System: D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,5,6-tris-O-(phenylmethyl)-3,4-O-(1S,2R,4S)-1,7,7-trimethylbicyclo2.2.1hept-2-ylidene-(196302-91-7)

Safety Data

• Hazardous Substances Data: 196302-91-7(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 196302-90-6 1D-2,5,6-tri-O-benzyl-3-O-endo,4-O-exo-(L-1',7',7'-trimethylbicyclo<2.2.1>hept-2'-ylidene)-myo-inositol 
• 196306-65-7 C₃₇H₄₄O₆ 

Downstream Products

• 180979-79-7 (-)-2,5,6-tri-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 3,4-bis(dibenzyl phosphate) 
• 180979-80-0 (+)-2,5,6-tri-O-benzyl-myo-inositol 3,4-bis(dibenzyl phosphate) 
• 187841-49-2 Phosphorous acid dibenzyl ester (1S,2R,3S,4S,5S,6S)-2,3,5-tris-benzyloxy-6-(bis-benzyloxy-phosphanyloxy)-4-(4-methoxy-benzyloxy)-cyclohexyl ester 

Relevant articles and documents

General synthesis of 3-phosphorylated mj'o-inositol phospholipids and derivatives

The D-3-phosphorylated wyo-inositol phospholipids PtdIns(3)P, PtdIns(3,4)P2, PtdIns(3,4,5)P3 and PtdIns(3,5)P2 were synthesised from /yo-inositol orthoformate 8. Key transformations included the regioselective DIBAL- and trimethylaluminium-mediated cleavages of wiyo-inositol orthoformate intermediates and a resolution-protection protocol using the camphor acetals 17. The final reductive debenzylation was effected with Pearlman's catalyst [Pd(OH)J in the presence of sodium hydrogen carbonate. The biological properties of the phospholipids were evaluated against various protein kinases (PKB and PDK-1) in which they played an important activation role.