196311-65-6

Usage

Uses

Used in Pharmaceutical Industry:
1-Cyclopropanecarbonitrile, 1-amino is used as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique structure allows for the development of new drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
1-Cyclopropanecarbonitrile, 1-amino is used as a building block in the production of agrochemicals, such as pesticides and herbicides. Its versatile chemical properties enable the creation of effective and targeted agrochemicals for agricultural use.
Used in Organic Synthesis:
1-Cyclopropanecarbonitrile, 1-amino serves as a starting material for the synthesis of more complex organic molecules. Its cyclopropane ring, nitrile, and amino group provide a foundation for further chemical reactions, leading to the formation of a wide range of compounds with diverse applications.
Used in Chemical Production:
1-Cyclopropanecarbonitrile, 1-amino is utilized in the production of other chemical compounds, expanding its applications beyond pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable component in the synthesis of various chemical products.

Upstream product

• 507264-68-8 tert-butyl (1-cyanocyclopropyl)carbamate 
• 127946-77-4 1-amino-1-cyclopropanecarbonitrile hydrochloride 

Downstream Products

• 507264-68-8 tert-butyl (1-cyanocyclopropyl)carbamate 
• 1611472-56-0 8-(4-chlorophenyl)-N-(1-cyanocyclopropyl)-1,6-naphthyridine-2-carboxamide 

Relevant academic research and scientific papers

Optimization strategy of single-digit nanomolar cross-class inhibitors of mammalian and protozoa cysteine proteases

Cysteine proteases (CPs) are involved in a myriad of actions that include not only protein degradation, but also play an essential biological role in infectious and systemic diseases such as cancer. CPs also act as biomarkers and can be reached by active-

Synthesis of: N -unsubstituted cycloalkylimines containing a 4 to 8-membered ring

Primary cycloalkylimines with a 4 to 8-membered ring were synthesized by dehydrocyanation of the corresponding α-aminonitriles on solid potassium hydroxide via a vacuum gas-solid reaction. Imine-enamine tautomerism has been demonstrated at room temperature for the most kinetically stable derivatives.

Method for easily and conveniently synthesizing 1-amino-1-nitrile-cyclopropane

The invention discloses a method for easily and conveniently synthesizing 1-amino-1-nitrile-cyclopropane. According to the method, 2,4-bromobutyronitrile is utilized as a starting material and reactswith phthalimide potassium under the base catalysis to generate phthalimide cyclopropanecarbonitrile, and then hydrazinolysis is carried out in ethanol to obtain the 1-amino-1-nitrile-cyclopropane. The method disclosed by the invention has the advantages of mild reaction conditions, relatively high yield, low cost and suitability for industrialized application.

Design, synthesis and antibacterial activity studies of novel quinoline carboxamide derivatives

A series of novel quinoline-6-carboxamides and 2-chloroquinoline-4- carboxamides were synthesized by the reaction of their analogous carboxylic acids with various amine derivatives in the presence of base TEA and protecting agent BOP at room temperature.

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C

A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in whole blood.