196397-51-0

Upstream product

• 77-76-9 2,2-dimethoxy-propane 
• 174742-33-7 (S)-Benzyloxycarbonylamino-[(1R,2R,3S,4R)-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,3-dihydroxy-cyclopentyl]-acetic acid benzyl ester 
• 196397-48-5 (+)-(3R,5S)-3-Azido-5-[(S)-benzyloxycarbonyl(benzyloxycarbonylamino)methyl]cyclopent-1-ene 
• 196397-49-6 (-)-(3R,5S)-3-Amino-5-[(S)-benzyloxycarbonyl(benzyloxycarbonylamino)methyl]cyclopent-1-ene 
• 196397-47-4 (S)-((1S,4R)-4-Azido-cyclopent-2-enyl)-benzyloxycarbonylamino-acetic acid 
• 174742-35-9 (-)-4-endo-Azido-2-oxabicyclo[3.3.0]oct-7-en-3-one 
• 174848-45-4 (-)-4-exo-Bromo-2-oxabicyclo[3.3.0]oct-7-en-3-one 
• 174742-36-0 (-)-4-endo-Amino-2-oxabicyclo[3.3.0]oct-7-en-3-one 
• 174742-32-6 (S)-Benzyloxycarbonylamino-[(1S,4R)-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopent-2-enyl]-acetic acid benzyl ester 
• 196397-50-9 (S)-Benzyloxycarbonylamino-[(1S,4R)-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopent-2-enyl]-acetic acid 
• 174742-31-5 (1S,4S,5R)-4-benzyloxycarbonylamino-2-oxabicyclo[3.3.0]oct-7-ene-3-one 
• 151765-22-9 (3S,3aR,6aR)-3-hydroxy-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-2-one 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 174742-33-7 (S)-Benzyloxycarbonylamino-[(1R,2R,3S,4R)-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2,3-dihydroxy-cyclopentyl]-acetic acid benzyl ester 

Relevant academic research and scientific papers

Total Synthesis of (±) carbocyclic polyoxin C and its α-epimer

Carbocyclic polyoxin C (2) and its α-epimer 3 were synthesized in racemic form in an efficient and diasteroedivergent fashion from cis-4-(N- tert-butylcarbamoyl)cyclopent-2-en-1-ol (5a). This synthesis features a Pd(0)-catalyzed substitution reaction, a novel, mild reduction of an α- nitro ester to an amino acid ester, and an improved procedure for uracil ring formation.

Asymmetric total synthesis of (+)-carbocyclic uracil polyoxin C

A short, practical, asymmetric synthesis of carbocyclic uracil polyoxin C is described. The key step in the synthesis is a regio- and stereo-selective palladium-mediated substitution reaction of an α-amino substituted unsaturated lactone with bis-silylate