196408-40-9

Basic information

• Product Name: acetic acid-(5-acetyl-2-chloro-anilide)
• Synonyms: acetic acid-(5-acetyl-2-chloro-anilide)
• CAS NO: 196408-40-9
• Molecular Weight: 211.648
• Mol File: 196408-40-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: acetic acid-(5-acetyl-2-chloro-anilide)(CAS DataBase Reference)
• NIST Chemistry Reference: acetic acid-(5-acetyl-2-chloro-anilide)(196408-40-9)
• EPA Substance Registry System: acetic acid-(5-acetyl-2-chloro-anilide)(196408-40-9)

Safety Data

• Hazardous Substances Data: 196408-40-9(Hazardous Substances Data)

Upstream product

• 99-03-6 1-(3-aminophenyl)ethanone 
• 7463-31-2 3-Acetamidoacetophenone 
• 79406-57-8 3-amino-4-chloroacetophenone 
• 108-24-7 acetic anhydride 

Downstream Products

• 861060-91-5 acetic acid-(5-acetyl-2-chloro-4-nitro-anilide) 
• 861060-93-7 acetic acid-(3-acetyl-6-chloro-2-nitro-anilide) 
• 13608-87-2 2',3',4'-trichloroacetophenone 
• 23082-51-1 4'-chloro-2'-nitroacetophenone 
• 6635-71-8 4,5-Dichloro-2-nitroacetophenone 
• 857560-75-9 1-(5-amino-4-chloro-2-nitro-phenyl)-ethanone 
• 855926-11-3 1-(3-amino-4-chloro-2-nitro-phenyl)-ethanone 
• 920751-44-6 N-[2-chloro-5-(3-dimethylamino-acryloyl)-phenyl]-acetamide 

Relevant articles and documents

Highly ortho-Selective Chlorination of Anilines Using a Secondary Ammonium Salt Organocatalyst

An organocatalytic, highly facile, efficient, and regioselective ortho-chlorination of anilines is described. A secondary ammonium chloride salt has been employed as the catalyst and the reaction can be conducted at room temperature without protection from air and moisture. In addition, the reaction is readily scalable and the catalyst can be recycled and reused. This catalytic protocol has been applied to the efficient synthesis of a highly potent c-Met kinase inhibitor. Mechanistic studies revealed that unique structural features of the secondary ammonium chloride salt are important for both the catalysis and regioselectivity of the electrophilic ortho-chlorination.