1964503-39-6

Basic information

• Product Name: Carboxy-PEG4-phosphonic acid ethyl ester
• Synonyms: Carboxy-PEG4-phosphonic acid ethyl ester
• CAS NO: 1964503-39-6
• Molecular Formula: C15H31O9P
• Molecular Weight: 386.375001
• Mol File: 1964503-39-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carboxy-PEG4-phosphonic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carboxy-PEG4-phosphonic acid ethyl ester(1964503-39-6)
• EPA Substance Registry System: Carboxy-PEG4-phosphonic acid ethyl ester(1964503-39-6)

Safety Data

• Hazardous Substances Data: 1964503-39-6(Hazardous Substances Data)

Usage

Description

Carboxy-PEG4-phosphonic acid ethyl ester is a versatile compound that features a carboxylic acid end group and a phosphonic acid ethyl ester moiety. This molecule is designed to enhance the water solubility of associated compounds in aqueous media, thanks to its hydrophilic PEG (polyethylene glycol) linker. The carboxylic acid group can readily react with primary amines in the presence of activation agents like EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) and HATU (1-(6-Hexahydro-1H-azepine-1-yl)-1H-1,2,3-triazole-4-carboxamidine), leading to the formation of a stable amide bond. This characteristic makes Carboxy-PEG4-phosphonic acid ethyl ester a valuable building block in the synthesis of various bioconjugates and pharmaceuticals.

Uses

Used in Bioconjugation:
Carboxy-PEG4-phosphonic acid ethyl ester is used as a linking agent for bioconjugation, facilitating the stable attachment of molecules to biomolecules such as proteins or peptides. The formation of amide bonds with primary amines enhances the stability and functionality of the resulting bioconjugates.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Carboxy-PEG4-phosphonic acid ethyl ester is used as a component in drug delivery systems. Its ability to form stable amide bonds allows for the efficient conjugation of drugs with targeting moieties or other therapeutic agents, potentially improving the drug's solubility, bioavailability, and targeted delivery to specific cells or tissues.
Used in Material Science:
Carboxy-PEG4-phosphonic acid ethyl ester can be utilized as a modifying agent in material science, where it can enhance the properties of various materials. By forming amide bonds with primary amine-containing materials, it can improve the hydrophilicity, stability, and overall performance of the material in different applications.
Used in Diagnostics:
In the diagnostics field, Carboxy-PEG4-phosphonic acid ethyl ester is used as a component in the development of diagnostic tools. Its reactivity with primary amines allows for the creation of stable conjugates with diagnostic markers or contrast agents, which can improve the sensitivity and specificity of diagnostic tests.
Overall, Carboxy-PEG4-phosphonic acid ethyl ester is a multifaceted compound with applications in various industries, including pharmaceuticals, bioconjugation, material science, and diagnostics, due to its unique chemical properties and ability to form stable amide bonds with primary amines.