19646-48-1

Upstream product

• 100-44-7 benzyl chloride 
• 19499-94-6 1-(benzyloxy)-2,3-dimethyl-4-nitrobenzene 
• 1207869-63-3 ethyl 3-(3-(benzyloxy)-2-methyl-6-nitrophenyl)-2-oxopropanoate 

Downstream Products

• 344936-52-3 ethyl 5-benzyloxy-1,4-dimethyl-1H-indole-2-carboxylate 
• 1207869-66-6 C₂₉H₂₅NO₃ 
• 1207869-65-5 5-(benzyloxy)-4-methyl-1H-indole-2-carbaldehyde 
• 1207869-67-7 (5-(benzyloxy)-4-methyl-1H-indol-2-yl)(4-phenoxyphenyl)methanone 
• 1207868-95-8 C₂₂H₁₇NO₃ 

Relevant academic research and scientific papers

Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5- hydroxyindole as a novel CaMKII inhibitor

Based on 2-(4-phenoxybenzoyl)-5-hydroxyindole (2), a novel structural class of CaMKII inhibitors were synthesized and further optimized. The strong acidity of the hydroxyl group and the lipophilic group at the 4 and 6-positions were found to be necessary for strong CaMKII inhibition. Compound 25 was identified as a promising compound with 50-fold more potent inhibitory activity for CaMKII than 2. Compound 25 also showed high selectivity for CaMKII over off-target kinases.