196491-79-9

Upstream product

• 100-51-6 benzyl alcohol 
• 116159-66-1 dimethyl 3-dimethyl(phenyl)silylpentan-1,5-dioate 
• 196491-73-3 dimethyl 2-methoxycarbonyl-3-dimethyl(phenyl)silyl-1,5-pentanedioate 
• 223436-83-7 3-(Dimethyl-phenyl-silanyl)-pentanedioic acid 
• 196491-68-6 3-[dimethyl(phenyl)silyl]glutaric anhydride 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 88761-82-4 methyl β-(E)-2-dimethylphenylsilylacrylate 
• 3839-31-4 dimethyl(phenyl)silyllithium 
• 41527-39-3 dimethyl (2E)-pent-2-enedioate 

Downstream Products

• 196491-90-4 (R)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(dimethyl-phenyl-silanyl)-5-oxo-pentanoic acid 
• 134208-73-4 (S)-3-Hydroxy-4-((S)-1-phenyl-ethylcarbamoyl)-butyric acid 
• 121331-23-5 (3S,1'S)-3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-5-[(1-phenylethyl)amino]-5-oxopentanoic acid, methyl ester 
• 223437-40-9 (S)-3-Hydroxy-4-((S)-1-phenyl-ethylcarbamoyl)-butyric acid methyl ester 
• 223437-38-5 (S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-hydroxy-5-oxo-pentanoic acid ((S)-1-phenyl-ethyl)-amide 
• 196491-87-9 [(1S,2S)-1-Benzyl-2-(dimethyl-phenyl-silanyl)-4-oxo-tridecyl]-carbamic acid benzyl ester 
• 223118-05-6 (S)-4-Benzyl-3-[(S)-3-(dimethyl-phenyl-silanyl)-4-(2-nonyl-[1,3]dioxolan-2-yl)-butyryl]-oxazolidin-2-one 
• 196491-83-5 (S)-1-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(dimethyl-phenyl-silanyl)-tetradecane-1,5-dione 
• 196491-85-7 (2R,3S)-2-Benzyl-3-(dimethyl-phenyl-silanyl)-4-(2-nonyl-[1,3]dioxolan-2-yl)-butyric acid methyl ester 
• 196491-88-0 (2S,3S,5R)-2-Benzyl-3-(dimethyl-phenyl-silanyl)-5-nonyl-pyrrolidine-1-carboxylic acid ethyl ester 
• 196491-84-6 (S)-3-(Dimethyl-phenyl-silanyl)-4-(2-nonyl-[1,3]dioxolan-2-yl)-butyric acid methyl ester 

Relevant academic research and scientific papers

Desymmetrization of prochiral anhydrides with Evans' oxazolidinones: An efficient route to homochiral glutaric and adipic acid derivatives

The prochiral recognition between enantiotopic carbonyl groups in the reaction of 3-substituted glutaric and 3,4-disubstituted adipic anhydrides with anions of Evans' oxazolidinones has been investigated. Each of the σ-symmetric anhydrides provided a diastereoisomeric mixture of half-acids which were separated either by fractional crystallization or by column chromatography of their esters. The diastereoselectivity of the desymmetrization reaction is dependent on the substituents present in the anhydrides.

A silicon controlled total synthesis of the antifungal agent (+)-preussin

A stereoselective total synthesis of (+)-preussin has been achieved from a meso anhydride featuring a dimethyl(phenyl)silyl group as a masked hydroxy group which also restricts elimination reactions, stereodirects hydrogenation and ester enolate alkylation, and facilitates Curtius reaction.