196494-75-4

Upstream product

• 6605-22-7 3,5:6,7-bis-O-(1-methylethylidene)-α-D-glucoheptonic γ-lactone 
• 196494-67-4 Trifluoro-methanesulfonic acid (R)-((2R,3S,4S)-4-azido-5-oxo-3-triethylsilanyloxy-tetrahydro-furan-2-yl)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl ester 
• 196494-69-6 Trifluoro-methanesulfonic acid (R)-((2R,3S,4S)-4-amino-5-oxo-3-triethylsilanyloxy-tetrahydro-furan-2-yl)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl ester 
• 196494-65-2 (3S,4S,5S)-3-Azido-5-[(R)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-4-triethylsilanyloxy-dihydro-furan-2-one 
• 196494-71-0 (2S,3S,4S,5R)-5-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-3-triethylsilanyloxy-pyrrolidine-2-carboxylic acid methyl ester 
• 196494-63-0 (3S,4S,5R)-3-Azido-5-[(R)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-4-hydroxy-dihydro-furan-2-one 
• 191352-58-6 2-azido-2-deoxy-3,5:6,7-di-O-isopropylidene-D-glycero-D-ido-heptono-1,4-lactone 
• 130481-75-3 Trifluoro-methanesulfonic acid (4R,4aS,7R,7aR)-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-6-oxo-tetrahydro-furo[3,2-d][1,3]dioxin-7-yl ester 

Downstream Products

• 196494-77-6 (2S,3S,4S,5R)-3,4-Dihydroxy-2,5-bis-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Inhibition of UDP-Gal mutase and mycobacterial galactan biosynthesis by pyrrolidine analogues of galactofuranose

Some pyrrolidine analogues of galactofuranose - synthesised from carbohydrate lactones - are the first known inhibitors of E. coli K12 UDP-Gal mutase and mycobacterial galactan biosynthesis. This inhibition may form chemotherapeutic strategy for the treatment of human pathogens which contain integral galactofuranosyl structures such as tuberculosis and leprosy.