196495-52-0Relevant academic research and scientific papers
Preparation of methylene-gem-difluorocyclopropanes and its reactivity as Michael Acceptor
Taguchi, Takeo,Kurishita, Masahito,Shibuya, Akira,Aso, Kifune
, p. 9497 - 9508 (1997)
Preparation of methylene-gem-difluorocyclopropanes 3 was achieved through the selenoxide elimination reaction derived from gem- difluorocyclopropylmethanols 1, while this method can not be applied to non- fluorinated cyclopropylmethanols. The methylene-gem-difluorocyclopropane 3 showed a high reactivity as a Michael acceptor in the reaction with thiol or amine.
Stereoselective synthesis of versatile 2-chloromercurium-3,5-syn-dihydroxy esters via intramolecular oxymercuration
Bonini, Carlo,Campaniello, Maria,Chiummiento, Lucia,Videtta, Valeria
, p. 8766 - 8772 (2008/12/23)
Regio- and stereocontrolled alkoxy mercuration of α,β-unsaturated esters allows direct access to 1,3-syn diols in good yields. Demercuration of adducts leads to 1,3 skipped dihydroxy esters, alcohols, and α-halo esters. The deprotection of acetonide with Amberlyst 15 on 1,3-syn-dihydroxy esters gives the corresponding δ-lactones.
