1965-63-5Relevant academic research and scientific papers
Novel synthesis of 3-aminopropionitriles by ring opening of 2-oxazolidinones with cyanide ion
Taniguchi, Tsuyoshi,Goto, Naoya,Ishibashi, Hiroyuki
supporting information; experimental part, p. 4857 - 4858 (2009/10/26)
Nucleophilic attack of cyanide ion on the 5-position of 2-oxazolidinones in the presence of 18-crown-6 gave 3-aminopropionitriles.
An efficient ZrCl4 catalyzed aza-michael addition reaction: Synthesis of C-linked carbo β3-amino acids
Damera, Krishna,Reddy, Katta L.,Sharma, Gangavaram V.M.
experimental part, p. 151 - 155 (2010/04/23)
A mild aza-Michael protocol has been developed using ZrCl4 as catalyst on α, β-unsaturated esters and nitriles. The aromatic amines were found to give the products with ease. The ZrCl4 mediated route was compatible with acid sensitive carbohydrate esters and provided an efficient method to prepare C-linked carbo β3-amino acids (β3-Caa).
RuCl3 in poly(ethylene glycol): A highly efficient and recyclable catalyst for the conjugate addition of nitrogen and sulfur nucleophiles
Zhang, Huaxing,Zhang, Yuhong,Liu, Leifang,Xu, Hailiang,Wang, Yanguang
, p. 2129 - 2136 (2007/10/03)
The 1,4-conjugate addition of primary, secondary and aromatic amines, thiols, and carbamate to α,β-unsaturated compounds mediated by a catalytic amount (0.5 mol%) of RuCl3 in poly(ethylene glycol) (PEG) provides the desired β-substituted carbonyls in high yields. In particular, we found that primary aliphatic and aromatic amines produced the single adducts as the sole products in very high yields with RuCl3-PEG. RuCl 3-PEG was readily recycled via solvent precipitation with efficient recyclability as evidenced by high yields. Its properties of low sensitivity toward moisture and oxygen, high tolerance of different functional groups, and efficient recyclability make RuCl3-PEG suitable for both laboratory and industrial scale synthesis of β-substituted carbonyls. Georg Thieme Verlag Stuttgart.
