196501-04-9Relevant academic research and scientific papers
Synthesis and evaluation of a novel series of pseudo-cinnamic derivatives as antituberculosis agents
Yoya, Georges Koumba,Bedos-Belval, Florence,Constant, Patricia,Duran, Hubert,Daffe, Mamadou,Baltas, Michel
, p. 341 - 343 (2009)
In an effort to develop potent new antituberculous drugs effective against Mycobacterium tuberculosis, we have prepared series of cinnamic derivatives (thioesters and amides) with 4-hydroxy and 4-alkoxy groups and investigated the in vitro activities of these compounds. Among them some displayed a good in vitro antibacterial activity, such as (E)-N-(2-acetamidoethyl)-3-{4-[(E)-3,7-dimethylocta-2,6-dienyloxy]phenyl}acrylamide 4b that showed a minimum inhibitory concentration of 0.1 μg/mL (0.26 μM) against M. tuberculosis H37Rv.
