196504-69-5

Upstream product

• 31281-28-4 2'-mercapto-2'-deoxyuridine 
• 1054662-45-1 Acetic acid (2R,3R,4R,5R)-2-acetoxymethyl-4-[bis-(4-methoxy-phenyl)-phenyl-methylsulfanyl]-5-[2-oxo-4-(2,4,6-triisopropyl-benzenesulfonyloxy)-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 
• 196504-64-0 2'-S-(4,4'-Dimethoxytrityl)-2'-thiouridine 
• 83088-00-0 2'-deoxy-2'-(4-methoxyphenylmethanethio)uridine 

Relevant academic research and scientific papers

Synthesis of 2'-thio-uridine and -cytidine derivatives as potential inhibitors of ribonucleoside diphosphate reductase: thionitrites, disulfides and 2'-thiouridine 5'-diphosphate

In order to study or/and inhibit ribonucleotide reductase, thio derivatives of uridine and cytidine which can interact with the reducing cysteines at the active site have been prepared.The first nucleosidic thionitrites 12 and 15 have been synthesized from 2'-thiouridine 4 and 2'-thiocytidine 11, respectively and their ability to generate spontaneously nitric oxide, a potent inhibitor of Escherichia coli ribonucleotide reductase (RDPR), has been evidenced.The 2'-thiol function in 2'-thiouridine is protected as a mixed disulfide to obtain the stable and useful precursor 18 of 2'-thiouridine 5'-diphosphate 19 which has been found strongly to inhibit RDPR.The same protection has been successfully used during the conversion of 2'-thiouridine into 2'-thiocytidine.