19654-38-7

Upstream product

• 84265-06-5 O-(4-formylphenyl) dimethylcarbamothioate 

Downstream Products

• 854016-19-6 (E)-3-(4-dimethylcarbamoylsulfanylphenyl)-2-fluoroacrylic acid ethyl ester 
• 53339-53-0 4-mercaptobenzyl alcohol 
• 91358-96-2 4-mercaptobenzaldehyde 
• 84265-05-4 S-[p-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl]phenyl]dimethylthiocarbamate 
• 84265-06-5 O-(4-formylphenyl) dimethylcarbamothioate 

Relevant academic research and scientific papers

A Mechanism-Based Approach to Screening Metagenomic Libraries for Discovery of Unconventional Glycosidases

Functional metagenomics has opened new opportunities for enzyme discovery. To exploit the full potential of this new tool, the design of selective screens is essential, especially when searching for rare enzymes. To identify novel glycosidases that employ cleavage strategies other than the conventional Koshland mechanisms, a suitable screen was needed. Focusing on the unsaturated glucuronidases (UGLs), it was found that use of simple aryl glycoside substrates did not allow sufficient discrimination against β-glucuronidases, which are widespread in bacteria. While conventional glycosidases cannot generally hydrolyze thioglycosides efficiently, UGLs follow a distinct mechanism that allows them to do so. Thus, fluorogenic thioglycoside substrates featuring thiol-based self-immolative linkers were synthesized and assessed as selective substrates. The generality of the approach was validated with another family of unconventional glycosidases, the GH4 enzymes. Finally, the utility of these substrates was tested by screening a small metagenomic library.

COMPOUNDS FOR THE PREVENTION AND TREATMENT OF MEDICAL DISORDERS AND USES THEREOF

Aspects of the invention relate to compounds, pharmaceutical compositions, methods for the manufacturing of compounds and methods for treatment of various disorders mediated at least in part by one or more galectins.

Porphyrin compound and preparation method and application thereof in surface enhanced Raman probe

The invention relates to a porphyrin compound and a preparation method and an application thereof in a surface enhanced Raman probe. The porphyrin compound is 5-[4-(N,N-dimethylamino formyl)phenyl]-15-(4-carboxyl phenyl)porphyrin, and has the structure represented by the formula (I). One end of the prepared porphyrin compound is a carboxyl group which can be firmly adsorbed on the surface of titanium dioxide, and the other end of the prepared porphyrin compound is thiol ester which is adsorbed on a silver surface to form an S-Ag bond. Titanium dioxide nanoparticles and silver nanoparticles form a stable and ordered composite material under connective action of the molecule, and a stable and ordered SERS substrate is formed. The mark molecule is not only a template agent for the substrate but also has a stable signal on the substrate, and has a broad application prospect.

A thiol-thiosulfonate reaction providing a novel strategy for turn-on thiol sensing

The first thiol-specific turn-on probe, BODIPY-TS, utilizing a thiosulfonate scaffold as the thiol recognition unit was reported. BODIPY-TS displays low toxicity, and features high sensitivity, fast response and quantitative reaction towards thiols. The structural novelty of BODIPY-TS would guide the development of novel thiol probes.

ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

A compound of formula (I) : (wherein R1-R10 are each independently hydrogen, halogen, optionally substituted lower alkyl or the like, X1 is -O-, -S-, -NR11- (wherein R11 is hydrogen, lower alkyl or the like), -CR12R13CO-, -(CR12R13)mO-, -O(CR12R13)m- (wherein R12 and R13 are each independently hydrogen or lower alkyl and m is a integer between 1 and 3) or the like, X2 is a bond, -O-, -S-, -NR14- (wherein R14 is hydrogen, lower alkyl or the like, R14 and R6 can be taken together with the neighboring atom to form a ring) or -CR15R16-(wherein R15 and R16 are each independently hydrogen or lower alkyl, R15 and R6 or R10 can be taken together with the neighboring carbon atom to form a ring, R16 and R9 can be joined together to form a bond), X3 is COOR17, C( = NR17)NR18OR19 or the like), a pharmaceutically acceptable salt or a solvate thereof.