196622-43-2Relevant academic research and scientific papers
Synthesis of pyrimido[5″,4″:5′,6′]pyrido[2′,3′:4,5]- thieno[2,3-c]pyridazine and pyridazino[4′3′:4,5]-thieno[3,2-b][1,8]naphthyridine, new tetrahete-rocyclic ring systems
Quintela, José M.,Veiga, M. Carmen,Peinador, Carlos,Gonzalez, Liliana
, p. 1733 - 1743 (2007/10/03)
Preparation of a number of pyrimido[5″,4″:5′,6′]pyrido-[2′,3′:4,5] thieno[2,3-c]pyridazine derivatives (4a-h) has been effected by reaction of appropriately heterocyclic aminonitrile precursor (1) and N,N-dimethyldichloromethyleniminium chloride. In addition, pyridazino[4′,3′:4,5]-thieno[3,2-b][1,8]naphthyridines (9a-i), were prepared via the Friedl?nder synthesis of the N-heteroaromatic carbaldehyde (8) with acyclic, cyclic, heterocyclic or α,β-unsaturated ketones and other active methylene compounds.
