19673-12-2

Usage

Uses

Used in Oncology:
Hexahydro-5-oxo-1-(phenylmethyl)-1H-azepine-4-carboxylic acid ethyl ester is used as an anticancer agent for the treatment of various types of cancer. It has been investigated as a potential treatment for colorectal, gastric, and breast cancer, showing promise in clinical trials. Its mechanism of action involves inhibiting the activity of the enzyme dihydropyrimidine dehydrogenase, which enhances the anticancer effects of 5-fluorouracil.
Used in Pharmaceutical Industry:
Hexahydro-5-oxo-1-(phenylmethyl)-1H-azepine-4-carboxylic acid ethyl ester is used as a key intermediate in the synthesis of pharmaceutical compounds, particularly those with anticancer properties. Its unique chemical structure allows for the development of new drugs that can target specific cancer cells and pathways, offering potential therapeutic benefits for patients.
Further research is needed to fully understand the potential therapeutic applications of Hexahydro-5-oxo-1-(phenylmethyl)-1H-azepine-4-carboxylic acid ethyl ester and to optimize its use in cancer treatment.

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 1065114-13-7 2,7-dibenzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepin-4-one 
• 1065113-64-5 7-benzyl-2-(3-chlorobenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one 
• 635698-46-3 7-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine-2,4(1H,3H)-dione 
• 635698-48-5 7-Benzyl-2,4-dichloro-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine 
• 1065114-18-2 2,7-dibenzyl-4-methoxy-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine 
• 1065114-20-6 2,7-dibenzyl-4-methyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine 
• 1065111-00-3 2-benzyl-4-methoxy-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine 
• 1309870-76-5 C₂₃H₂₂F₃N₃O 
• 1065113-91-8 7-benzyl-2-(4-fluorobenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one 
• 1065113-71-4 7-benzyl-2-(4-chlorobenzyl)-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-d]azepin-4-one 
• 1065113-76-9 7-benzyl-2-(4-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine 
• 1065113-68-9 7-benzyl-2-(3-chlorobenzyl)-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to inhibitors of one or more isoforms of RAS, such as inhibitors of one or more of KRAS, HRAS and NRAS, or mutants thereof, such as G12D, G12V, G13D or G12C mutants thereof. Therapeutic methods of treating conditions and dis

BICYCLIC PYRIMIDINE DERIVATIVES

[wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m + n is 4 or less; R1 represents NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, -C(=O)-, -SO2-, -OC(=O)- or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like]ψBicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.