1968-28-1

Basic information

• Product Name: 4H-Imidazol-4-one,3,5-dihydro-
• Synonyms: 2-Imidazolin-4(or5)-one (5CI); 2-Imidazolin-4-one (6CI,8CI); 2-Imidazolin-5-one (7CI); 4H-Imidazol-4-one, 1,5-dihydro- (9CI); 1-Imidazolin-5-one; NSC 382330
• CAS NO: 1968-28-1
• Molecular Formula: C₃H₄N₂O
• Molecular Weight: 84.0767
• Mol File: 1968-28-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 137.3°Cat760mmHg
• Flash Point: 36.8°C
• Density: 1.44g/cm³
• CAS DataBase Reference: 4H-Imidazol-4-one,3,5-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Imidazol-4-one,3,5-dihydro-(1968-28-1)
• EPA Substance Registry System: 4H-Imidazol-4-one,3,5-dihydro-(1968-28-1)

Safety Data

• Hazardous Substances Data: 1968-28-1(Hazardous Substances Data)

Usage

General Description

4H-Imidazol-4-one, 3,5-dihydro- is a chemical compound with the molecular formula C3H6N2O. It belongs to the class of imidazoles and is commonly used in the field of organic chemistry. 4H-Imidazol-4-one,3,5-dihydro- is characterized by a five-membered ring structure containing two nitrogen atoms and one oxygen atom. It is a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals, as well as being used in the production of dyes and other organic compounds. 4H-Imidazol-4-one, 3,5-dihydro- is notable for its diverse applications in different industries, making it an important chemical compound in the field of organic synthesis and chemistry.

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Relevant articles and documents

Conversion of imidazoles to imidazolones with chloramine-B: kinetic and mechanistic study

Oxidative conversion of 1H-imidazole (IzlH) and 2-substituted imidazoles viz., 2-ethyl-1H-imidazole (2-EtIzlH), 2-methyl-1H-imidazole (2-MeIzlH), 1H-imidazole-2-ester (2-EsIzlH), and 1H-imidazole-2-carbaldehyde (2-CaIzlH) to the corresponding imidazolones with sodium N-chlorobenzenesulfonamide or chloramine-B (CAB) were established. This reaction was kinetically investigated at 303?K in HClO4 medium. Under comparable experimental conditions, the oxidation reactions followed identical kinetics for all the five imidazoles with a first-order dependence of rate on [CAB]o and fractional-order dependence each on [imidazole]o and [H+]. Effects of added benzenesulfonamide, halide ions, NaClO4, and MeOH on the rate of reaction have been studied. Reaction products were identified and characterized by GC–MS and NMR spectral analysis. The rates are measured at different temperatures and the composite activation parameters have been computed from the Arrhenius plots. Isokinetic temperature (β) was found to be 449?K which is higher than the experimental temperature (303?K), indicating that the rate has been under enthalpy control. Relative reactivity of these imidazoles is in the order: 2-EtIzlH?>?2-MeIzlH?>?IzlH?>?2-EsIzlH?>?2-CaIzlH. H2O+Cl have been postulated as the reactive oxidizing species. The reaction mechanism and the derived rate law are in good agreement with the observed experimental results. Spectroscopic studies have been made for an intermediate complex formation between CAB and imidazole. Advantages of the present method include: mild reaction conditions, cost-effectiveness, short reaction time, ease of isolation of products, and the use of eco-friendly reagents. Hence, the methodology developed could be adopted for the facile oxidative conversion of imidazoles to imidazolones and can be scaled up to industrial operation with suitable modification. Graphical abstract: [Figure not available: see fulltext.]

IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

The present disclosure is directed to compounds of formula (Ie) and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, m, n, X1, X2, X3 and X4 are as defined herein, which are active as inhibitors of S-Nitrosoglutathione reductase (GSNOR). These compounds prevent, inhibit, or suppress the action of GSNOR and are therefore useful in the treatment of GSNOR mediated diseases, disorders, syndromes or conditions such as, e.g., pulmonary hypertension, acute respiratory distress syndrome (ARDS), asthma, bronchospasm, cough, pneumonia, pulmonary fibrosis, interstitial lung diseases, cystic fibrosis and chronic obstructive pulmonary disease (COPD).

Imidazolines N-substituted by a biphenylmethyl group, their medical use and the pharmaceutical compositions therefor

The invention relates to compounds of the formula STR1 in which X and R1 -R5 are defined in the specification and their salts where appropriate, all of which are useful as angiotensin II antagonists.