196861-64-0

Upstream product

• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 151024-14-5 [(2R,4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]methanol 

Downstream Products

• 196861-71-9 (R)-4-Hydroxy-3-(4-methoxy-benzyloxy)-butyric acid tert-butyl ester 
• 196861-57-1 (R)-3-(4-Methoxy-benzyloxy)-4-oxo-butyric acid tert-butyl ester 
• 196861-69-5 (R)-3-(4-Methoxy-benzyloxy)-4-triisopropylsilanyloxy-butyric acid 
• 196861-70-8 (R)-3-(4-Methoxy-benzyloxy)-4-triisopropylsilanyloxy-butyric acid tert-butyl ester 
• 196861-60-6 (R)-3-(4-Methoxy-benzyloxy)-4-triisopropylsilanyloxy-butan-1-ol 

Relevant academic research and scientific papers

Toward a total synthesis of an aglycone of spiramycin; a chiron approach to the C-1/C-4 and the C-13/C-15 fragments

Acetalisation of p-anisaldehyde by either (R) or (S)-butanetriol has been shown to occur selectively and quantitatively by using Noyori's protocol. The crystalline dioxane derivatives R-6a and S-6a which formed respectively in these conditions have been converted efficiently into the title fragments of spiramycin.

A synthetic approach to the phorboxazoles—synthesis of the exocyclic fragment

A strategy for the total synthesis of the phorboxazoles, including the synthesis of the exocyclic fragment corresponding to the C33–C41 portion, is reported. The primary objective was to utilize a chelation-controlled addition to an α-alkoxyaldehyde to install the oxygen atom at the C38 position.