196862-46-1

Basic information

• Product Name: (R)-3-(benzyloxy)-4-chloro-butanenitrile
• Synonyms: (R)-3-(benzyloxy)-4-chloro-butanenitrile
• CAS NO: 196862-46-1
• Molecular Weight: 209.675
• Mol File: 196862-46-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3-(benzyloxy)-4-chloro-butanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(benzyloxy)-4-chloro-butanenitrile(196862-46-1)
• EPA Substance Registry System: (R)-3-(benzyloxy)-4-chloro-butanenitrile(196862-46-1)

Safety Data

• Hazardous Substances Data: 196862-46-1(Hazardous Substances Data)

Upstream product

• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 84367-31-7 (R)-γ-chloro-β-hydroxybutyronitrile 

Downstream Products

• 177948-70-8 (3R)-N(H)-3-(benzyloxy)pyrrolidine 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF CHIRAL 3-HYDROXY PYRROLIDINE COMPOUND AND DERIVATIVES THEREOF HAVING HIGH OPTICAL PURITY

The present invention relates to an effective process for the preparation of optically pure chiral 3-hydroxypyrrolidine or derivatives thereof. More particularly, the present invention relates to an efficient process for the preparation of chiral 3-hydroxypyrrolidine or derivatives thereof, comprised of introducing a suitable protecting group to the starting material 4-chloro-3-hydroxybutyronitrile. Introduction of the hydroxy-protecting group provides advantages: efficient prevention of formation of side products, enhanced performance of the reduction of the nitrile group of the starting material, and enhanced performance of in-situ in? tramolecular cyclization. The chiral 3-hydroxypyrrolidine compound is produced in high yield and with high purity.