196883-19-9Relevant academic research and scientific papers
α-Methoxy-benzylmetals: Original synthesis and reactivity
Krief, Alain,Bousbaa, Jamal
, p. 6289 - 6290 (1997)
Although 1-methoxy-1-methylseleno-toluene is efficiently metallated by KDA, the same compound as well as its higher homologues react with t-butyllithium producing 1-methoxy benzyllithiums via the C-Se bond cleavage. These species are efficiently alkylated by alkyl halides, even the secondary ones and react with THF in the presence of BF3-OEt2 to produce the homologated tetrahydropyran derivative in good yield.
