196936-80-8

Basic information

• Product Name: (2S,5R)-1-(2-Ethoxycarbonyl-3-phenyl-propionyl)-5-(3-hydroxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester
• Synonyms: (2S,5R)-1-(2-Ethoxycarbonyl-3-phenyl-propionyl)-5-(3-hydroxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester
• CAS NO: 196936-80-8
• Molecular Weight: 433.545
• Mol File: 196936-80-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,5R)-1-(2-Ethoxycarbonyl-3-phenyl-propionyl)-5-(3-hydroxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-1-(2-Ethoxycarbonyl-3-phenyl-propionyl)-5-(3-hydroxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester(196936-80-8)
• EPA Substance Registry System: (2S,5R)-1-(2-Ethoxycarbonyl-3-phenyl-propionyl)-5-(3-hydroxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester(196936-80-8)

Safety Data

• Hazardous Substances Data: 196936-80-8(Hazardous Substances Data)

Upstream product

• 607-81-8 diethyl 2-benzylmalonate 
• 196936-75-1 (2S,5R)-5-(3-Hydroxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester 

Downstream Products

• 188127-08-4 ({(S)-3-[((3S,9aS)-6-Benzyl-5-oxo-octahydro-pyrrolo[1,2-a]azepine-3-carbonyl)-amino]-2-oxo-piperidin-1-yl}-imino-methyl)-carbamic acid benzyl ester 
• 196936-91-1 ({(S)-3-[((3S,9aS)-6-Benzyl-5-oxo-octahydro-pyrrolo[1,2-a]azepine-3-carbonyl)-amino]-2-hydroxy-piperidin-1-yl}-imino-methyl)-carbamic acid benzyl ester 
• 196936-84-2 (2S,5R)-5-(3-Bromo-propyl)-1-(2-ethoxycarbonyl-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 196936-88-6 (3S,9aS)-6-Benzyl-5-oxo-octahydro-pyrrolo[1,2-a]azepine-3-carboxylic acid tert-butyl ester 
• 188126-96-7 (3S,9aS)-6-Benzyl-5-oxo-octahydro-pyrrolo[1,2-a]azepine-3-carboxylic acid 
• 196936-82-0 (2S,5R)-1-(2-Ethoxycarbonyl-3-phenyl-propionyl)-5-(3-methanesulfonyloxy-propyl)-pyrrolidine-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Design and synthesis of conformationally constrained arginal thrombin inhibitors

A series of conformationally constrained arginal thrombin inhibitors was prepared starting from 5,6 or 5,7 bicyclic lactamic structures, that an indirect approach of X-ray structure-based drug design indicated as D-Phe-Pro dipeptide mimetics. The tetrahydrocquinolyl sulfonamido derivative Ig (LR-D/009) displayed the best inhibitory potency (IC50 = 0.018 μm), with good selectivity over plasmin and trypsin.