196939-45-4Relevant articles and documents
First synthesis of cytotoxic 8,9-secokaurene diterpenoids. An enantioselective route to (-)-O-methylshikoccin and (+)- O-methylepoxyshikoccin
Paquette, Leo A.,Backhaus, Dirk,Braun, Ralf,Underiner, Ted L.,Fuchs, Klaus
, p. 9662 - 9671 (2007/10/03)
A practical route for the total synthesis of 8,9-secokaurene diterpenes is described. The central step is the 3.3]sigmatropic rearrangement of spirocyclic intermediates such as 35, 40, and 41. All three compounds must necessarily respond identically to pr