196953-16-9

Upstream product

• 487-68-3 mesytaldehyde 
• 103594-35-0 1-(2,4,6-trimethylphenyl)but-3-yn-1-ol 

Downstream Products

• 81698-99-9 1,3,5-trimethyl 2-(α-furyl)benzene 
• 914661-82-8 5-(2,4,6-trimethyl-phenyl)-furan-2-carbaldehyde 
• 914662-07-0 2-(2-nitrovinyl)-5-(2,4,6-trimethyl-phenyl)-furan 
• 914662-13-8 4-methyl-N-{2-[5-(2,4,6-trimethyl-phenyl)-furan-2-yl]-ethyl}-benzenesulfonamide 
• 914662-19-4 4-methyl-N-prop-2-ynyl-N-{2-[5-(2,4,6-trimethyl-phenyl)-furan-2-yl]-ethyl}-benzenesulfonamide 

Relevant academic research and scientific papers

A bicyclization reaction with two molecular allenyl ketones and isocyanides: Synthesis of a lactone-containing azaspirocycle derivative

A novel bicyclization reaction of two molecular allenyl ketones and isocyanides has been disclosed. This strategy allows for the construction of structurally complex spirocyclic lactam-lactone systems in an efficient manner. This protocol also demonstrate

Gold catalysis: No steric limitations in the phenol synthesis

Different dihydroisoindol-4-ols and 8-hydroxytetrahydroisoquinolines were prepared by the gold-catalyzed phenol synthesis. The reaction was investigated with several sterically demanding groups in the 5-position of the furan starting material. The influen

C-C-Bond Formation by the Palladium-Catalyzed Cycloisomerization/Dimerization of Terminal Allenyl Ketones: Selectivity and Mechanistic Aspects

The scope of the palladium-catalyzed cyclization/dimerization of terminal allenyl ketones 1 to the 2,4-disubstituted furans 3 has been investigated. Simplified and improved conditions almost exclusively provided the dimer 3, accompanied by only traces of the easily separable monomer 2. The formation of an isomer of 3, the unconjugated ketone 4, was completeley suppressed. Under these mild conditions, besides the normal functional group tolerance known for palladium-catalyzed reactions, an interesting selectivity was observed with functional groups that are known to react either in palladium-catalyzed reactions or reactions catalyzed by other transition-metals. Thus aryl halides, terminal alkynes, 1,6-enynes, and α-allenic alcohols were tolerated. In the latter example the selective reaction of only one out of two different allenes was achieved. Mechanistic investigation indicated a Pd(II)/Pd(IV)-cycle involving palladium(II)-γ-alkoxyvinylcarbene and furylpalladium(IV) hydride intermediates, although a second pathway for the formation of the dimer 3 which also involves Pd(IV)-intermediates like the 3,4-dimethylenepalladacyclopentane 23 and the 3-methylenepalladacyclobutane-like structure 15 (respectively 25) could not completely be excluded.