196959-32-7Relevant academic research and scientific papers
Enantioselective construction of alicyclic bicyclo[3.1.0]hexane framework by double stereodifferentiation and its application for the synthesis of both enantiomers of vitamin D3 CD ring synthons
He, Mingqi,Tanimori, Shinji,Ohira, Susumu,Nakayama, Mitsuru
, p. 13307 - 13314 (2007/10/03)
Good diastereoselectivity (85:15) was observed in the intramolecular cyclopropanation of the chiral unsaturated α-diazo-β-keto ester 9f, which possesses (R)-pantolactone as a chiral auxiliary. The reaction was catalyzed by a chiral bis-oxazoline copper (1) complex 17. The absolute stereochemistry of each generated diastereomer (10f and 11f was elucidated. Both enantiomers of the vitamin D3 CD ring synthons ((-)-21 and (+)-22) were synthesized from (-)12 and (+)-13, respectively.
