196959-68-9Relevant academic research and scientific papers
Imidazo[1,2]hetarylglyoxylates: Synthesis and reactivity toward nucleophiles
Zamkova, Irina A.,Chekotylo, Oleksiy O.,Geraschenko, Oleksandr V.,Grygorenko, Oleksandr O.,Mykhailiuk, Pavel K.,Tolmachev, Andrey A.
, p. 1692 - 1696 (2010)
A practical approach to imidazo[1,2]hetarylglyoxylates via Friedel-Crafts acylation of the parent fused imidazoles with ethyl oxalyl chloride is reported. The reaction is strongly influenced by the electron-donating properties of the starting heterocycle. The generated imidazo[1,2]hetarylglyoxylates undergo standard transformations typical of -keto esters upon reaction with various nucleophiles. All the products contain an imidazoheterocyclic scaffold which is considered a privileged structure for drug discovery. Georg Thieme Verlag Stuttgart - New York.
