196960-46-0

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 123-72-8 butyraldehyde 
• 111-92-2 dibutylamine 

Relevant academic research and scientific papers

Direct β-C(sp3)-H Functionalization of Aliphatic Amines to α,β-Unsaturated Imines, Aldehydes, and Chromenes

A metal-free method for direct β-C(sp3)-H functionalization of aliphatic amine was developed. The method is based on a reaction that yields enamine directly from the corresponding aliphatic amine, which otherwise requires the aid of metallic reagent and/or external oxidant. The reaction is operationally simple, general, and highly efficient in functionalizing both cyclic and acyclic amines. Structurally diverse unsaturated imines were obtained from N-heterocycles, while acyclic amines provided 2-alkyl cinnamaldehyde and benzopyran derivatives with excellent E/Z-selectivity.

Synthesis of substituted hexa-3,5-dienoic acid methyl esters from conjugated dienones

Substituted hexa-3,5-dienoic acid methyl esters (2) were conveniently prepared in one step by 1,2-carbonyl transposition of the corresponding dienones (1) using lead(IV) acetate and boron trifluoride-diethyl ether in benzene at room temperature.