197016-31-2

Upstream product

• 197016-30-1 Carbonic acid 4-((5R,5aR,8aS)-9-azido-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester benzyl ester 
• 6559-91-7 4'-demethylepipodophyllotoxin 
• 23363-33-9 4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin 
• 518-28-5 podofilox 
• 1208364-57-1 4β-chloroacetamido-4'-demethyl-4'-benzyloxycarbonyl-4-deoxypodophyllotoxin 

Downstream Products

• 1208364-51-5 4-β-vinylsulfonylamino-4'-benzyloxycarbonyl-4'-demethyl-4-deoxypodophyllotoxin 
• 1208364-58-2 1-{3-[4-(3-tert-butoxycarbonylaminopropyl)-tert-butoxycarbonylaminobutyl]-tert-butoxycarbonylaminopropyl}-3β-[9-(4-benzyloxycarbonyloxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-urea 
• 1208364-63-9 C₆₃H₉₀N₆O₁₈ 
• 117507-84-3 (5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one 

Relevant academic research and scientific papers

NEW (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA, OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, A PROCESS FOR PREPARING THEM, AND APPLICATION THEREOF IN THERAPY AS ANTICANCER AGENTS

The present invention relates to new derivatives of epipodophyllotoxin 4-substituted with an optionally substituted (poly)aminoalkylaminoalkylamidc, or alkyl-urea or alkyl- sulfonamide chain, a process for preparing them and their use as a medicine as an anticancer agent. Formula (1) wherein: - R represents hydrogen or C1-4alkyI, - A represents CO(CH2)n or CONH(CH2)n where n = 2, 3, 4, or 5, - R1 and R2 are as described herein.

Stereo and chemoselective enzymatic reduction of azido functionality: Synthesis of 4-β-Aminopodophyllotoxin congeners by Baker's yeast

4β-Aminopodophyllotoxin congeners have been synthesized by the stereoselective biocatalytic reduction of the 4-azidopodophyllotoxins employing baker's yeast in excellent yields under mild conditions.