197021-75-3

Upstream product

• 19316-85-9 5'-azido-5'-deoxythymidine 
• 197021-63-9 C₅₅H₇₀N₅O₁₀PSi₂ 
• 342608-85-9 C₃₉H₅₂N₅O₁₀PSi 
• 179017-20-0 (S)-[(2S,3S,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-(1,1-diethoxy-ethyl)-phosphinic acid ethyl ester 
• 179017-24-4 (R)-[(2S,3S,5R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-(1,1-diethoxy-ethyl)-phosphinic acid ethyl ester 
• 179017-27-7 [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid ethyl ester 
• 179017-27-7 [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl]-phosphinic acid ethyl ester 
• 146557-62-2 3'-O-tert-Butyldiphenylsilyl-5'-azido-5'-deoxythymidine 
• 179015-84-0 5'-O-(tert-butydiphenylsilyl)-3'-deoxy-3'-C-(iodomethyl)thymidine 
• 146557-63-3 5'-Amino-3'-tert-butyldiphenylsilyl-5'-deoxythymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 197021-71-9 C₂₃H₃₄N₅O₁₀P 

Relevant academic research and scientific papers

Stereochemical assignment and stereoselective synthesis of 3′-C-P-N-5′ Rp-ethyl phosphonamidate modified nucleic acid

The configuration of the duplex stabilising 3′-C-P-N-5′ ethyl phosphonamidate nucleic acid backbone modification has been identified as Rp following the preparation of cyclic nucleoside analogues and NOE studies. Complimentary routes for formation of the key phosphonamidate nitrogen to phosphorus bond from stereochemically defined H-phosphinate intermediates, involving both a retention and inversion at the phosphorus centre, have been identified.