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(1E)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N'-hydroxyethanimidamide, also known as TH5487, is a synthetic compound developed as a potential therapeutic agent. It is a small molecule inhibitor of the enzyme prolyl hydroxylase domain (PHD), which is involved in the regulation of hypoxia-inducible factor (HIF) and has been implicated in various diseases, including cancer, anemia, and ischemic conditions. TH5487 has been studied for its ability to stabilize HIF and promote erythropoiesis, the process of red blood cell production, making it a potential treatment for anemia and other hypoxia-related disorders.

197083-26-4

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197083-26-4 Usage

Uses

Used in Pharmaceutical Industry:
TH5487 is used as a therapeutic agent for the treatment of anemia and other hypoxia-related disorders due to its ability to stabilize HIF and promote erythropoiesis.
Used in Oncology:
TH5487 is used as an anti-cancer agent for inhibiting the growth and survival of tumor cells, showing promising effects in the treatment of cancer.
Research into the therapeutic potential of TH5487 is ongoing, with hopes that it may lead to the development of new treatments for a range of medical conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 197083-26-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,0,8 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 197083-26:
(8*1)+(7*9)+(6*7)+(5*0)+(4*8)+(3*3)+(2*2)+(1*6)=164
164 % 10 = 4
So 197083-26-4 is a valid CAS Registry Number.

197083-26-4Upstream product

197083-26-4Relevant academic research and scientific papers

TETRAHYDROCARBAZOLES AND DERIVATIVES

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Page/Page column 91-92, (2010/02/14)

The present invention relates to compounds of the formula (I) wherein R1, R2, R3, R4, R5, X1, X2, X3, X4, n, and k are defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for in the treatment and prophylaxis of diseases which are modulated by LXRα and/or LXR? agonists, including increased lipid and cholesterol levels, particularly low HDL-cholesterol, high LDL-cholesterol, atherosclerotic diseases, diabetes, particularly non-insulin dependent diabetes mellitus, metabolic syndrome, dyslipidemia, Alzheimer's disease, sepsis, inflammatory diseases such as colitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as Alzheimer's disease or impaired/improvable cognitive function.

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