197094-10-3Relevant academic research and scientific papers
Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi
Varghese, Swapna,Rahmani, Rapha?l,Russell, Stephanie,Deora, Girdhar Singh,Ferrins, Lori,Toynton, Arthur,Jones, Amy,Sykes, Melissa,Kessler, Albane,Eufrásio, Amanda,Cordeiro, Artur Torres,Sherman, Julian,Rodriguez, Ana,Avery, Vicky M.,Piggott, Matthew J.,Baell, Jonathan B.
, p. 278 - 285 (2019)
Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, respectively. Together, these diseases affect 68 million people around the world. Current
HETEROCYCLIC COMPOUNDS AND USE OF SAME
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, (2016/01/08)
Novel heterocyclic compounds are provided which display useful efficacy in the treatment of diseases caused by trypanosomatids. Particularly, the compounds of the invention are useful in the treatment of HAT and/or Chagas disease and/or Animal African trypanosomiasis (AAT).
Novel Parham-type Cycloacylations of 1H-Pyrazole-1-alkanoic Acids
Larsen, Scott D.
, p. 1013 - 1014 (2007/10/03)
Exposure of 1H-pyrazole-1-alkanoic acids to two equivalents of n-butyllithium affords the corresponding cyclic ketones via a Parham-type cyclization process. Although yields are modest, this procedure represents a simple and direct intramolecular acylation of a non-nucleophilic pyrazole carbon.
