19715-56-1Relevant academic research and scientific papers
Identification of novel, selective and potent Chk2 inhibitors
Larson, Gary,Yan, Shunqi,Chen, Huanming,Rong, Frank,Hong, Zhi,Wu, Jim Zhen
, p. 172 - 175 (2007/10/03)
A series of isothiazole carboxamidine compounds were synthesized and discovered as novel and selective inhibitors for Chk2. They are not active against the related Chk1 kinase. The structure-activity relationship studies were performed on the scaffold, an
2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes
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Page/Page column 7, (2010/02/15)
The invention relates to 2-thiohydantoin compounds selected from compounds of general formula (I): in which, in particular, one of the radicals R1 and R2 comprises two aromatic rings in the structure or is the dibenzofuranyl group, R3 is a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group, a hydroxyl group, a phenyl group or a benzyl group, R4 is a hydrogen atom, a halogen atom or a C1-C4 alkyl group, and their addition salts with a non-toxic acid, especially the pharmaceutically acceptable salts. It further relates to the process for their preparation, to the pharmaceutical compositions in which they are present, and to their use as pharmacologically active substances, especially in the case of the treatment of diabetes, diseases due to hyperglycemia, hypertriglyceridemia, dyslipidemia or obesity.
Diaryl sulphide derivatives
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, (2008/06/13)
A diaryl sulphide derivative of the formula STR1 in which R1 represents a thiazolamino radical of the formulae STR2 wherein R5 represents hydrogen, alkyl, aralkyl or acyl, R6 and R6 ' are identical or different
