197151-90-9Relevant academic research and scientific papers
Synthesis and biological evaluation of receptor-based tumor imaging agent: 99mTc-folate-glucaric acid
Onursal, Mehmet,Lambrecht, Fatma Yurt,Ozgur, Aykut
, p. 288 - 292 (2011)
The aim of the present study was to prepare 99mTc-folate- glucaric acid and investigate the radiopharmaceutical potential for tumors imaging that over express folate receptor. Folate-glucaric acid was synthesized and the synthesized folate conjugate was confirmed with 1H NMR and LC-MS/MS methods. Folate-glucaric acid was labeled with 99mTc, and its radiolabelling efficiency was found as 96 ± 2.0%. Biodistribution study of 99mTc-folate-glucaric acid was carried out in vivo using two groups of female Albino Wistar rats: folate receptor (FR) saturated and unsaturated. Biodistribution study showed that 99mTc-folate-glucaric acid indicated high uptake in folate receptor rich tissues such as breast, ovary and uterus. Therefore, 99mTc-folate-glucaric acid shows good radiolabeling and biodistribution in FR organs, the radiolabeled conjugate is a reason potentially useful radiopharmaceutical for detection of FR-positive tumors.
