197159-33-4

Upstream product

• 122313-00-2 N-tert-butoxycarbonyl-L-aspartic acid α-tert-butyl ester β-N-methoxy-N-methylamide 
• 4440-01-1 lithium phenylacetylide 
• 536-74-3 phenylacetylene 
• 34582-32-6 N-tert-butoxycarbonyl aspartic acid tert-butyl ester 
• 80963-08-2 N-tert-butoxycarbonyl-L-aspartic acid β-benzyl α-tert-butyl diester 
• 94347-11-2 4-benzyl 1-t-butyl L-aspartate 

Downstream Products

• 197159-58-3 (S)-α-tert-butoxycarbonylamino-β-(2-p-chlorophenyl-6-phenylpyrimidin-4-yl)propanoic acid α-tert-butyl ester 
• 197159-55-0 (S)-α-tert-butoxycarbonylamino-β-(2-methylthio-6-phenylpyrimidin-4-yl)propanoic acid α-tert-butyl ester 
• 197159-79-8 (S)-α-tert-butoxycarbonylamino-β-(2-amino-6-phenylpyrimidin-4-yl)propanoic acid α-tert-butyl ester 
• 197159-70-9 (S)-α-tert-butoxycarbonylamino-β-(2-methylsulfonyl-6-phenylpyrimidin-4-yl)propanoic acid α-tert-butyl ester 

Relevant academic research and scientific papers

From aspartic acid to dihydropyridone-2-carboxylates: Access to enantiopure 6-substituted 4-oxo- and 4-hydroxypipecolic acid derivatives

We describe a method that starts from a protected (S)-aspartic acid and employs a gold-catalyzed cyclization to give enantiopure dihydropyridone 2-carboxylates, which are then converted into 6-substituted 4-oxo- and 4-hydroxypipecolic acid derivatives. Th

The synthesis of pyrimidin-4-yI substituted a-amino acids. a versatile approach from alkynyl ketones

The reaction of amidines with a-amino acid alkynyl ketones is shown to be a versatile route to pyrimidin-4-yl substituted a-amino acids. This route is also applicable to a parallel synthesis approach and has allowed the formation of a range of pyrimidin-4-yl substituted a-amino acids, including the naturally occurring a-amino acid L-lathyrine 4.

A versatile approach to pyrimidin-4-yl substituted α-amino acids from alkynyl ketones; the total synthesis of L-lathyrine

A range of pyrimidin-4-yl substituted α-amino acids has been synthesised by the reaction of amidines with α-amino acid alkynyl ketones.