19716-71-3Relevant academic research and scientific papers
Potential cancer chemopreventive activity of simple isoquinolines, 1-benzylisoquinolines, and protoberberines
Cui, Wenhua,Iwasa, Kinuko,Tokuda, Harukuni,Kashihara, Akiko,Mitani, Yosuke,Hasegawa, Tomoko,Nishiyama, Yumi,Moriyasu, Masataka,Nishino, Hoyoku,Hanaoka, Miyoji,Mukai, Chisato,Takeda, Kazuyoshi
, p. 70 - 79 (2008/02/04)
Seventeen simple isoquinolines, 15 1-benzylisoquinolines, and 19 protoberberines were tested for their inhibitory activities against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol- 13-acetate (TPA) in Raji cells. Among the tested alkaloids, the inhibitory activity of all 1-benzylisoquinolines and 11 protoberberines was higher than that of β-carotene. The 1-benzylisoquinolines 19, 21, 22, 29, and 34 and protoberberines 41, 47-49, 51, 52, and 55 showed potent inhibitory effects on EBV-EA induction (96-100% inhibition at 1 × 103 mol ratio/TPA). These alkaloids were more active than the naturally occurring alkaloids, 23, 25, 33, 53, and 54. In addition, fifteen simple isoquinolines, eighteen 1-benzylisoquinolines and eight protoberberines were evaluated with respect to their ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. Nine simple isoquinolines, ten 1-benzylisoquinolines, and four protoberberines were more potent than α-tocopherol, and four 1-benzylisoquinolines, 20 and 28-30, exhibited potent activities (SC50 4.5-5.8 μM). Their activities were higher than the naturally occurring alkaloids, 23, 25, and 33. Therefore, some of the isoquinoline alkaloids indicating the high activity on both assays may be potentially valuable cancer chemopreventive agents. Structure-activity relationships are discussed for both tests.
Berberis alkaloids XXXIX. New alkaloids from B. densiflora
Khamidov,Aripova,Telezhenetskaya,Karimov,Dzhenberov
, p. 323 - 325 (2007/10/03)
The alkaloid composition of the leaves of Berberis densiflora has been studied. Berberine, β-allocryptopine, oxyacanthine, glautine, thalicmidine, isocorydine, O-methylcorypalline and the new bases densinine and densiberine have been isolated. The structures of the new alkaloids have been established by a study of spectral characteristics and chemical transformations. This is the first time that any of the known alkaloids, apart from berberine, have been isolated from a plant of this species and it is the first time that β-allocryptopine and O-methylcorypalline have been isolated from the Berberis genus.
