197161-83-4Relevant academic research and scientific papers
Preparation of 3-(4-pyridinylamino)-1,2-benzisoxazoles via a nucleophilic aromatic substitution reaction
Fink, David M.,Kurys, Barbara E.
, p. 995 - 998 (1996)
An efficient three step process for the preparation of secondary 3-amino-1,2-benzisoxazoles is described. The key step is the isomerization/cyclization of an ortho halo or nitro amidoxime. The nucleophilic substitution reaction is successful with a wide variety of substituents on the aromatic ring, including an electron donating substituent para to the site of attack.
