197164-13-9

Upstream product

• 197163-99-8 (R)-(+)-2-methyl-2-(2-trans-methoxycarbonyl-1-ethenyl)-cyclopentanone 
• 197164-09-3 3-((R)-6-Methyl-1,4-dioxa-spiro[4.4]non-6-yl)-cyclohexa-1,4-dienecarboxylic acid methyl ester 
• 197163-97-6 3-((R)-6-Methyl-1,4-dioxa-spiro[4.4]non-6-yl)-propionic acid methyl ester 
• 197164-03-7 (E)-3-((R)-6-Methyl-1,4-dioxa-spiro[4.4]non-6-yl)-prop-2-en-1-ol 
• 197164-05-9 (E)-3-((R)-6-Methyl-1,4-dioxa-spiro[4.4]non-6-yl)-propenal 
• 197164-07-1 (R)-6-((E)-Buta-1,3-dienyl)-6-methyl-1,4-dioxa-spiro[4.4]nonane 
• 7424-82-0 methyl (1R)-3-(1-methyl-2-oxocyclopentyl)propanoate 
• 197164-01-5 (E)-3-((R)-6-Methyl-1,4-dioxa-spiro[4.4]non-6-yl)-acrylic acid methyl ester 

Downstream Products

• 197164-17-3 3-((S)-4-Methyl-spiro[2.4]hept-4-yl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of liverwort sesquiterpene (-)-isocuparene (herbertene) via a Diels-Alder reaction using phenylethylamine as chiral auxiliary

The imine of 2-methylcyclopentanone with (S)-(-)-phenylethylamine was subjected to reaction with methyl propiolate and the product was transformed into (-)-isocuparene by use of a Diels-Alder reaction to construct the aromatic ring.