197169-38-3Relevant academic research and scientific papers
Titanium chelation in regioselective Michael additions to conjugated dienones and trienones
Brocchini, Stephen J.,Lawton, Richard G.
, p. 6319 - 6322 (2007/10/03)
The site of Michael addition of β-hetero atom substituted thiols (such as mercaptoethanol) to unsubstituted 2, 4-dienone and 2, 4, 6-trienones is at the terminal (ω) position. This site preference is transferred to the β site when the addition is accomplished using Ti+4 complexation. These β site addition products rapidly rearrange to the ω position on base treatment.
