1971858-36-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(prop-1-en-2-yl)-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one is used as an impurity in the development and production of Filbanserin (F336750) for the treatment of hypoactive sexual desire disorder in females. Its presence in the drug may contribute to the overall pharmacological effects of Filbanserin, although its specific role in the treatment is not explicitly detailed in the provided materials.
As an impurity in Filbanserin, 1-(prop-1-en-2-yl)-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one may play a role in the drug's mechanism of action, which involves modulating the activity of serotonin and dopamine receptors. The compound's ability to bind dopamine receptors with relatively high affinity suggests that it could potentially influence the drug's efficacy and safety profile. Further research would be needed to determine the exact contribution of this impurity to the therapeutic effects of Filbanserin and its potential implications for patients.

Upstream product

• 81942-81-6 1-(2-Hydroxy-ethyl)-3-isopropenyl-1,3-dihydro-benzoimidazol-2-one 
• 76835-14-8 1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride 
• 136702-12-0 1-(2-chloro-ethyl)-3-isopropenyl-1,3-dihydro-benzoimidazol-2-one 
• 52099-72-6 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one 
• 136081-17-9 1-(2-bromoethyl)-3-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one 
• 95-54-5 1,2-diamino-benzene 
• 98-16-8 3-trifluoromethylaniline 

Relevant academic research and scientific papers

A new process for preparing flibanserin (by machine translation)

The invention discloses a new process for preparing of flibanserin. In order to 1 - isopropenyl - 2 - benzimidazolone as raw materials, first with 2 - bromo ethanol reaction, to produce intermediate 1, intermediate 1 generated by the reaction with a sulfo

A preparation method of flibanserin (by machine translation)

The invention discloses a method for preparing of flibanserin, includes the steps of: (1) compound I with dichloroethane reaction to obtain compound II, its without purification, directly with compound III reaction, to obtain the compound IV; (2) compound

Method for industrial-scale efficient preparation of high-quality Flibaserin

The invention discloses a method for industrial-scale efficient preparation of high-quality Flibaserin, and belongs to the technical field of drug synthesis. The method comprises the following steps: A, putting benzimidazolone shown in Formula I and dihal

A Facile Route of Synthesis for Making Flibanserin

A novel and efficient route of synthesis for making flibanserin via 2-ethoxy-1H-benzo[d]imidazole (12) was described with excellent yield. This protocol provided a more facile approach to flibanserin.

PROCESS FOR THE PREPARATION OF FLIBANSERIN INVOLVING NOVEL INTERMEDIATES

The present invention related to process for the preparation of flibanserin involving novel intermediates. 1,3-dihydro-1-(2-bromoethyl)- 3-isopropenyl-2H-benzimidazol-2-one reacts with diethanolamine and converting the obtained dihydroxy compound to 1,3-dihydro- 1-[2-[N-[bis-(2-chloroethyl)amino]ethyl]-3-isopropenyl-2H-benzimidazol-2-one followed by depotection to obtain 1,3-dihydro- 1-[2-[N-bis-(2-chloroethyl)amino]ethyl]-1,2-H-benzimidazol-2-one. This on condensing with m-trifluoromethyl aniline gives flibanserin hydrochloride.