19719-28-9Relevant articles and documents
An improved method for the synthesis of phenylacetic acid derivatives via carbonylation
Li, He,Zhang, Yijun,Liu, Dinghua,Liu, Xiaoqin
, p. 548 - 552 (2019/11/13)
2,4-Dichlorophenylacetic acid is synthesized in high yield via the carbonylation of 2,4-dichlorobenzyl chloride, and various experimental conditions are evaluated. Xylene, bistriphenylphosphine palladium dichloride, tetraethylammonium chloride and sodium hydroxide in solution are added to the reaction system and held at 80 °C under a CO atmosphere. 2,4-Dichlorophenylacetic acid is obtained in a maximum yield of 95percent, and a mechanism for 2,4-dichlorobenzyl chloride carbonylation is proposed. The reaction system provides a mild, effective and novel means by which to prepare phenylacetic acid derivatives from their corresponding benzyl chloride derivatives.
Technological method for preparing halogenated-3,4-dihydro-1H-2-naphthalenone
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, (2017/07/20)
The invention relates to a technological preparation method of halogenated-3,4-dihydro-1H-2-naphthalenone as shown in a formula (I). (As shown in the description). According to the method disclosed by the invention, through a cheap raw material namely 2,4-dihalogeno-benzene carbonitrile, and an intermediate namely 2,4-dihalogeno-benzene acetic acid is synthesized, and through a reusable trifluoroacetic anhydride/acid system catalyst, a target product namely the halogenated-3,4-dihydro-1H-2-naphthalenone is synthesized. According to the method disclosed by the invention, a large quantity of catalysts such as aluminumtrichloride, and costly catalysts such as Rh, are not needed, and the reaction route can be shortened, so that a large quantity of reagents and time can be saved, and the industrial economic benefits can be greatly increased.
Spirodiclofen and spiromesifen - Novel acaricidal and insecticidal tetronic acid derivatives with a new mode of action
Bretschneider, Thomas,Benet-Buchholz, Jordi,Fischer, Reiner,Nauen, Ralf
, p. 697 - 701 (2007/10/03)
The broad spectrum acaricides spirodiclofen (BAJ2740, trade name: Envidor) and spiromesifen (BSN2060, trade name: Oberon) with an additional excellent activity against whiteflies, both belong to the new chemical class of tetronic acid derivatives discovered at Bayer CropScience during the 1990s. The discovery process starting from herbicidal PPO (protoporphyrinogen oxidase) chemistry, the synthetic routes leading to the products, and some insight into process development of central intermediates is given. Spirodiclofen and spiromesifen have a new mode of action (interference with lipid biosynthesis), show no cross-resistance to any resistant mite or whitefly field population and are therefore valuable tools for resistance management.