1972-05-0Relevant articles and documents
CATALYTIC CANNABINOID PROCESSES AND PRECURSORS
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, (2020/12/07)
The present disclosure relates to new cannabinoid sulfonate esters and processes for their use to prepare cannabinoids. The disclosure also relates to the use of catalysts and catalytic processes for the preparation of cannabinoids from the cannabinoid sulfonate esters.
O-Methyl Phytocannabinoids: Semi-synthesis, Analysis in Cannabis Flowerheads, and Biological Activity
Caprioglio, Diego,Allegrone, Gianna,Pollastro, Federica,Valera, Stefano,Lopatriello, Annalisa,Collado, Juan A.,Munoz, Eduardo,Appendino, Giovanni,Taglialatela-Scafati, Orazio
, p. 981 - 986 (2019/08/20)
A general protocol for the selective mono-O-methylation of resorcinyl phytocannabinoids was developed. The availability of semisynthetic monomethyl analogues of cannabigerol, cannabidiol, and cannabidivarin (1a-3a, respectively) made it possible to quanti
Enantioselective Total Synthesis of Cannabinoids - A Route for Analogue Development
Shultz, Zachary P.,Lawrence, Grant A.,Jacobson, Jeffrey M.,Cruz, Emmanuel J.,Leahy, James W.
, p. 381 - 384 (2018/01/27)
A practical synthetic approach to Δ9-tetrahydrocannabinol (1) and cannabidiol (2) that provides scalable access to these natural products and should enable the generation of novel synthetic analogues is reported.
A One-Step Method for the α-Arylation of Camphor. Synthesis of (-)-Cannabidiol and (-)-Cannabidiol Dimethyl Ether
Vaillancourt, Valerie,Albizati, Kim F.
, p. 3627 - 3631 (2007/10/02)
The syntheses of (-)-cannabidiol and (-)-cannabidiol dimethyl ether were accomplished via fragmentation of an appropriately substituted 9-bromocamphor derivative.A new method of α-arylation of 3,9-dibromocamphor was shown to provide a variety of α-arylated camphor derivatives in good yields.
BORON TRIFLUORIDE ETHERATE ON ALUMINA - A MODIFIED LEWIS ACID REAGENT. AN IMPROVED SYNTHESIS OF CANNABIDIOL.
Baek, Seung-Hwa,Srebnik, Morris,Mechoulam, Raphael
, p. 1083 - 1086 (2007/10/02)
Boron trifluoride etherate on alumina catalyses the condensation of resorcinols and monomethyl resorcinols with several monoterpenoid allylic alcohols: in contrast to paralell reactions with boron trifluoride etherate in solution the products obtained do not undergo further cyclisations.