197219-15-1

Basic information

• Product Name: 6-[(4-methoxyphenyl)methoxy]-2-hexyn-1-ol
• Synonyms: 6-[(4-methoxyphenyl)methoxy]-2-hexyn-1-ol
• CAS NO: 197219-15-1
• Molecular Weight: 234.295
• Mol File: 197219-15-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-[(4-methoxyphenyl)methoxy]-2-hexyn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[(4-methoxyphenyl)methoxy]-2-hexyn-1-ol(197219-15-1)
• EPA Substance Registry System: 6-[(4-methoxyphenyl)methoxy]-2-hexyn-1-ol(197219-15-1)

Safety Data

• Hazardous Substances Data: 197219-15-1(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2746-25-0 p-Methoxybenzyl bromide 
• 5390-04-5 pent-1-yn-5-ol 
• 198411-17-5 1-((3-iodopropoxy)methyl)-4-methoxybenzene 
• 50-00-0 formaldehyd 
• 197219-01-5 1-methoxy-4-pent-4-ynyloxymethyl-benzene 

Downstream Products

• 69086-72-2 (+)-lycoperdic acid 
• 146554-64-5 methyl (5S,8S)-7-tert-butoxycarbonyl-2,6-dioxo-1-oxa-7-azaspiro<4.4>nonane-8-carboxylate 
• 292046-38-9 (5S,8S)-6-Oxo-1-oxa-7-aza-spiro[4.4]nonane-7,8-dicarboxylic acid 7-tert-butyl ester 8-methyl ester 
• 292046-29-8 (Z)-1-(tert-butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene 
• 292046-34-5 (S)-2-tert-Butoxycarbonylamino-4-[2-hydroxy-eth-(Z)-ylidene]-7-(4-methoxy-benzyloxy)-heptanoic acid methyl ester 
• 292046-35-6 (S)-2-tert-Butoxycarbonylamino-3-{(2R,3S)-3-hydroxymethyl-2-[3-(4-methoxy-benzyloxy)-propyl]-oxiranyl}-propionic acid methyl ester 
• 1025953-11-0 2-tert-butoxycarbonylamino-6-(tert-butyl-dimethyl-silanyloxy)-4-[3-(4-methoxy-benzyloxy)-propyl]-hex-4-enoic acid methyl ester 
• 197219-17-3 (2E)-1-(tert-butyldiphenylsilyloxy)-6-(4-methoxybenzyloxy)-2-hexene 
• 197219-47-9 (S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(2R,3aR,7aS)-hexahydro-furo[3,2-b]pyran-2-yl-ethanol 
• 197219-44-6 (4R,5R,7S,8S)-1-bromo-9-(tert-butyldiphenylsilyloxy)-4,5,7,8-diepoxynonane 
• 197219-49-1 (4S,5S,7S,8S)-1-bromo-9-(tert-butyldiphenylsilyloxy)-4,5,7,8-diepoxynonane 

Relevant articles and documents

Asymmetric synthesis of (-)-swainsonine, (+)-1,2-di-epi-swainsonine, and (+)-1,2,8-tri-epi-swainsonine

The asymmetric synthesis of (-)-swainsonine via a nonchiral pool route that involves the Sharpless epoxidation to induce chirality is reported. The key steps involve vinyl epoxide aminolysis, ring-closing metathesis, and intramolecular N-alkylation to prepare the indolizidine ring and a highly diastereoselective cis-dihydroxylation using AD-mix-α. This synthetic strategy also allowed for the diastereoselective synthesis of (+)-1,2-di-epi-swainsonine and (+)-1,2,8-tri-epi-swainsonine.

The biomimetic construction of fused cyclic polyethers

The formation of fused cyclic ethers by biomimetic synthesis was demonstrated. The one-pot successive ring-expansion reactions of bromo diepoxides were investigated by regarding the epoxy groups as the nucleophiles for the intramolecular cationic carbons to obtain the fused cyclic ethers.