197219-15-1

Upstream product

• 50-00-0 formaldehyd 
• 197219-01-5 1-methoxy-4-pent-4-ynyloxymethyl-benzene 
• 5390-04-5 pent-1-yn-5-ol 
• 824-94-2 p-methoxybenzyl chloride 
• 198411-17-5 1-((3-iodopropoxy)methyl)-4-methoxybenzene 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 307497-66-1 (5Z)-9-(4'-methoxybenzyloxy)-1-(oxan-2'-yloxy)-5-nonen-2-yne 
• 197219-17-3 (2E)-1-(tert-butyldiphenylsilyloxy)-6-(4-methoxybenzyloxy)-2-hexene 
• 197219-47-9 (S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(2R,3aR,7aS)-hexahydro-furo[3,2-b]pyran-2-yl-ethanol 
• 197219-44-6 (4R,5R,7S,8S)-1-bromo-9-(tert-butyldiphenylsilyloxy)-4,5,7,8-diepoxynonane 
• 197219-49-1 (4S,5S,7S,8S)-1-bromo-9-(tert-butyldiphenylsilyloxy)-4,5,7,8-diepoxynonane 

Relevant academic research and scientific papers

Asymmetric synthesis of (-)-swainsonine, (+)-1,2-di-epi-swainsonine, and (+)-1,2,8-tri-epi-swainsonine

The asymmetric synthesis of (-)-swainsonine via a nonchiral pool route that involves the Sharpless epoxidation to induce chirality is reported. The key steps involve vinyl epoxide aminolysis, ring-closing metathesis, and intramolecular N-alkylation to prepare the indolizidine ring and a highly diastereoselective cis-dihydroxylation using AD-mix-α. This synthetic strategy also allowed for the diastereoselective synthesis of (+)-1,2-di-epi-swainsonine and (+)-1,2,8-tri-epi-swainsonine.

Stereocontrolled synthesis of (+)-lycoperdic acid based on a palladium catalyzed reaction using a serine-derived organozinc reagent

An efficient stereocontrolled synthesis of (+)-lycoperdic acid has been achieved based on palladium catalyzed cross-coupling reaction of (Z)-1-(tert- butyldimethylsiloxy)-3-iodo-6-(p-methoxybenzyl)oxy-2-hexene with the organozinc reagent, prepared from N-Boc-β-iodoalanine methyl ester. (C) 2000 Elsevier Science Ltd.

The biomimetic construction of fused cyclic polyethers

The formation of fused cyclic ethers by biomimetic synthesis was demonstrated. The one-pot successive ring-expansion reactions of bromo diepoxides were investigated by regarding the epoxy groups as the nucleophiles for the intramolecular cationic carbons to obtain the fused cyclic ethers.