197226-96-3

Upstream product

• 18800-69-6 ((3aR,4R,6R,6aR)-6-(6-methoxy-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 
• 15888-39-8 ((3aR,4R,6R,6aR)-2,2-dimethyl-6-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl acetate 
• 76-83-5 trityl chloride 
• 197226-93-0 9-[(2S,3R,4R)-(5,4-dihydroxy-2,3-isopropylidenedioxy)pentyl]-6-methoxypurine 

Downstream Products

• 197227-00-2 9-[(2S,3S)-(2,3-isopropylidenedioxy-5-trityloxy-4-pentanone)-1-yl]-6-methoxypurine 

Relevant academic research and scientific papers

New neplanocin analogues. 10. The conversion of adenosine to neplanocin A, a carbocyclic nucleoside antibiotic with potent antiviral activity

Synthesis of neplanocin A, a potent antiviral carbocyclic nucleoside, from adenosine was achieved. An acyclic adeninenucleoside 21, prepared from adenosine, was converted to 4'-keto acyclic derivative 27. When 27 was treated with lithiotrimethylsilyldiazomethane in THF, a C-H insertion reaction at the 1'-position proceeded to give 6'-O-TBS-2',3'-O-isopropyrideneneplanocin A (29) along with its 1'-epimer 30.