197227-41-1Relevant academic research and scientific papers
The synthesis of indanones related to combretastatin A-4 via microwave-assisted Nazarov cyclization of chalcones
Lawrence, Nicholas J.,Armitage, E. Simon M.,Greedy, Benjamin,Cook, Darren,Ducki, Sylvie,McGown, Alan T.
, p. 1637 - 1640 (2006)
A fast and efficient microwave-assisted synthesis of combretastatin A-4-like indanones has been developed. Microwave irradiation provides a useful alternative to traditional heating techniques to promote the TFA-catalyzed Nazarov cyclization of chalcones.
Phenolic constituents of liquorice. VII. A new chalcone with a potent radical scavenging activity and accompanying phenolics from liquorice
Hatano, Tsutomu,Takagi, Miyuki,Ito, Hideyuki,Yoshida, Takashi
, p. 1485 - 1492 (1997)
Twenty-three phenolics including six new compounds were isolated from a commercial liquorice from North-eastern China. Structures 2-7 were assigned for the new compounds, designated as tetrahydroxy-methoxychalcone, isolicopyranocoumarin, glycyrrhiza-flavonol A, and glycyrrhiza-isoflavones A, B and C, respectively. Compound 2 showed the most potent scavenging effect on 1,1-diphenyl-2-picrylhydrazyl radical among the tested polyphenols isolated from liquorice. Air-oxidation of 2 in alkaline dimethylsulfoxide solution gave strong ESR signals, indicating the stability of the radical species formed from 2.
