197229-11-1Relevant academic research and scientific papers
NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE
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Paragraph 0101; 0102, (2018/05/24)
Provided is a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2. The present invention relates to a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION. The compound has a selective MMP-9 production suppressive action, and is useful as a drug for the prophylaxis and/or treatment of autoimmune diseases such as rheumatoid arthritis and the like, inflammatory bowel diseases (ulcerative colitis, Crohn's disease) or osteoarthritis.
An efficient access to the enantiomers of α-methyl-4-carboxyphenylglycine via a hydantoin route using a practical variant of preferential crystallization. AS3PC (auto seeded programmed polythermic preferential crystallization)
Ndzie,Cardinael,Schoofs,Coquerel
, p. 2913 - 2920 (2007/10/03)
The enantiomers are obtained in preparative amounts without a resolving agent via the following sequence: hydantoin synthesis, resolution by entrainment, and ring cleavage by means of hydrolysis in basic conditions. The new variant of preferential crystal
