197246-52-9

Upstream product

• 197246-49-4 (3R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]-oxy]-3-methyl-5-phenylmethoxy-1-pentene 
• 157542-41-1 (2R,3R)-1-benzyloxy-3-methyl-4-penten-2-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 197246-57-4 [4S,6R,11R,4'S,1R,2S,1'E]-2,2-dimethyl-11-[2,4-dimethyl-5-[(tert-butyldimethylsilyl)oxy]-1-pentenyl]-4-[1-methyl-2-[(tert-butyldimethylsilyl)oxy]-3-phenylmethoxy-propyl]-1,3,7-trioxaspiroundecan-9-one 
• 197246-56-3 (4S,6R,1'R,2'S)-2,2-dimethyl-4-[1-methyl-2-[(tert-butyldimethylsilyl)-oxy]-3-phenylmethoxy-propyl]-1,3,7-trioxa-spiroundec-10-en-9-one 
• 197246-55-2 (αS,1'R,2'S)-α-[1-methyl-2-[(tert-butyldimethylsilyl)-oxy]-3-phenylmethoxy-propyl]-5-hydroxymethyl-2-furaneethanol 
• 197246-53-0 (1R,1'R,2'S)-1-[1-methyl-2-[(tert-butyldimethylsilyl)-oxy]-3-phenylmethoxy-propyl]-oxirane 

Relevant academic research and scientific papers

Total synthesis of FK-506. Part 1: Construction of the C16-C34 fragment

The C23-C27 1,3-diol was constructed via either Brown's crotylation - osmylation or regio- and stereoselective opening of an 2,9-anhydro-β-ribofuranoside derived from D-xylofuranose. Lewis acid catalyzed epoxide opening with a protected lithiofurfural alc