197247-93-1Relevant academic research and scientific papers
Novel and efficient transformation of α-amino nitrile to α-imino and α-amide nitriles in asymmetric Strecker synthesis
Namba, Kosuke,Kawasaki, Masanori,Takada, Ichinori,Iwama, Seiji,Izumida, Masashi,Shinada, Tetsuro,Ohfune, Yasufumi
, p. 3733 - 3736 (2001)
Oxidation of α-amino nitrile 4 with ozone gave rise to a mixture of α-imino nitrile 5 and a novel fragmentation product of 6 in one-step. The mixture was converted to a variety of α-substituted α-amino acids 7 in high yields, which enabled the asymmetric transferring Strecker synthesis to be a widely useful method.
