197250-40-1Relevant academic research and scientific papers
Development of a continuous flow photoisomerization reaction converting isoxazoles into diverse oxazole products
Bracken, Cormac,Baumann, Marcus
, p. 2607 - 2617 (2020/03/11)
A continuous flow process is presented, which directly converts isoxazoles into their oxazole counterparts via a photochemical transposition reaction. This results in the first reported exploitation of this transformation to establish its scope and synthe
Simple Synthesis of 3-Oxopropanenitriles via Electrophilic Cyanoacetylation of Heterocycles with Mixed Anhydrides
Andicsovà-Eckstein, Anita,Kozma, Erika,Végh, Daniel
, p. 1945 - 1949 (2016/11/24)
A simple and efficient method for the synthesis of 3-oxopropanenitriles from variously substituted heterocyclic compounds via direct electrophilic cyanoacetylation is described. A series of heterocyclic 3-oxopropanenitriles (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k) have been synthesized using mixed anhydride (acetic or trifluoroacetic anhydride:cyanoacetic acid) in the presence of Mg(ClO4)2·2H2O as catalyst. This method can be extended also for the cyanoacetylation of electron poor aromatic compounds.
