19730-12-2

Usage

Uses

Used in Pharmaceutical Research and Development:
N-(pyridin-3-ylmethyl)propan-2-amine is utilized as a research reagent for its potential pharmacological properties, particularly in the development of treatments for neurological disorders, psychiatric disorders, and substance abuse. Its unique structure allows it to be a promising candidate for drug discovery and medicinal chemistry.
Used in Organic Chemistry:
In the realm of organic chemistry, N-(pyridin-3-ylmethyl)propan-2-amine is employed as a building block in the synthesis of various pharmaceuticals and organic compounds. Its distinctive chemical structure makes it a valuable component in creating new and innovative molecules for a range of applications.
Used in Biochemistry Studies:
N-(pyridin-3-ylmethyl)propan-2-amine also plays a role in biochemistry, where it is used to study the interactions and mechanisms of biological systems. Its presence in research can contribute to a better understanding of complex biochemical processes and the development of targeted therapies.

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 75-31-0 isopropylamine 
• 83987-95-5 C₉H₁₂N₂ 

Downstream Products

• 1424330-31-3 C₂₁H₂₂Cl₂N₄O₂ 

Relevant academic research and scientific papers

Zirconium Catalyzed Hydroaminoalkylation for the Synthesis of α-Arylated Amines and N-Heterocycles

The zirconium catalyzed hydroaminoalkylation of alkenes with N-aryl- and sterically demanding N-alkyl-α-arylated secondary amines by using commercially available Zr(NMe2)4 is reported. N-phenyl- and N-isopropylbenzylamine are used as amine substrates to establish the alkene substrate scope. Exclusively linear products are obtained in the presence of bulky vinylsilanes. Challenging α-heteroarylated amines and functionalized alkene substrates are compatible with this easy to use catalyst, affording a new disconnection strategy for the atom- and step-economic preparation of selectively substituted saturated α-arylated heterocycles.

Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries

Optimization of a high-throughput screening hit led to the discovery of a new series of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as highly potent agonists of TGR5. This novel chemotype was rapidly developed through iterative combinatorial library synthesis. It was determined that in vitro agonist potency correlated with functional activity data from human peripheral blood monocytes.