19730-13-3

Usage

Uses

Used in Pharmaceutical Industry:
N-(pyridin-3-ylmethyl)propan-1-amine is used as an intermediate in the synthesis of pharmaceuticals for its ability to form complex molecules due to its amine and pyridine functional groups. This contributes to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, N-(pyridin-3-ylmethyl)propan-1-amine serves as an intermediate in the synthesis of various agrochemicals, including pesticides and herbicides. Its unique chemical structure allows for the creation of effective compounds that can protect crops and enhance agricultural productivity.
Used in Organic Chemistry Research:
N-(pyridin-3-ylmethyl)propan-1-amine is utilized as a versatile building block in organic chemistry research for the synthesis of complex organic compounds. Its amine and pyridine functional groups enable the formation of a wide range of molecules, making it an essential component in advancing the field of organic chemistry.

InChI:InChI=1/C9H14N2/c1-2-5-10-7-9-4-3-6-11-8-9/h3-4,6,8,10H,2,5,7H2,1H3

Upstream product

• 120739-67-5 N-(pyridin-3-ylmethylene)-n-propylamine 
• 500-22-1 3-pyridinecarboxaldehyde 
• 107-10-8 propylamine 

Relevant academic research and scientific papers

Picolyl alkyl amines as novel tyrosinase inhibitors: Influence of hydrophobicity and substitution

Several novel picolyl alkyl amine derivatives (A-L) were synthesized, and the influence of hydrophobicity and substitution on the inhibition of mushroom tyrosinase toward both monophenolase and dlphenolase activities are described, α-, β-, and γ-picolyl amines are neither the substrates nor the inhibitors; however, the inhibition Is induced by the incorporation of an alkyl chain. The inhibition was strongly dependent on the substitution on a pyridine ring, and the inhibition follows the trend of a-picolyl alkyl amines (A, D, G) β-picolyl alkyl amines (B, E, H) γ -picolyl alkyl amines (C, F, I). The inhibition kinetics have been investigated, and γ-substituted derivatives were found to be a mixed type of inhibitor, whereas β-substituted derivatives were found to exhibit uncompetitive inhibition toward the oxidation of L-DOPA.

Pyrrolidine-modified and 6-substituted analogs of nicotine: a structure-affinity investigation

Because the structural requirements for the binding of nicotine to central nicotine receptors remain largely uninvestigated, we undertook a systematic investigation of pyrrolidine ring-opened analogs.This led to a subsequent investigation of related conformationally restricted derivatives of these analogs.The results are reported relative to the binding of several well-known and widely used nicotine receptor ligands.Although none of the ring-opened analogs binds with higher affinity than (-)-nicotine (Ki = 2.3 nM), 3-(N-methyl-N-ethylaminomethyl)pyridine (12a; Ki = 28 nM) binds with significant affinity.A conformationally restricted analog of 12a, N-methyl naphthyridine 30b (Ki = 18 nM), binds with similar affinity. 6-Substitution of 12a and racemic nicotine seems to be tolerated when the substituent is halogen or methyl.In functional studies (hypolocomotion and antinociception in mice; stimulus generalization in nicotine-trained rats) 30b retains nicotine-like properties.Several of the 6-substituted compounds were 2 to 20 times more potent than (+/-)nicotine.Although the intact pyrrolidine ring of nicotine appears important for optimal affinity, its presence is not an absolute requirement for activity, and 6-position substitution of the pyridine nucleus can influence both binding and functional activity. - Keywords: nicotine; nicotine receptor; drug discrimination; antinociception.