19735-44-5

Basic information

• Product Name: 2,3,4,5-Tetrahydro-8-(trifluoromethyl)-1H-pyrido[4,3-b]indole
• Synonyms: 2,3,4,5-Tetrahydro-8-(trifluoromethyl)-1H-pyrido[4,3-b]indole;8-(Trifluoromethyl)-2,3,4,50tetrahydro-1H-pyrido[4,3-b]indole;8-(trifluoromethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
• CAS NO: 19735-44-5
• Molecular Formula: C₁₂H₁₁F₃N₂
• Molecular Weight: 240.22
• Mol File: 19735-44-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.347
• CAS DataBase Reference: 2,3,4,5-Tetrahydro-8-(trifluoromethyl)-1H-pyrido[4,3-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-Tetrahydro-8-(trifluoromethyl)-1H-pyrido[4,3-b]indole(19735-44-5)
• EPA Substance Registry System: 2,3,4,5-Tetrahydro-8-(trifluoromethyl)-1H-pyrido[4,3-b]indole(19735-44-5)

Safety Data

• Hazardous Substances Data: 19735-44-5(Hazardous Substances Data)

Usage

General Description

2,3,4,5-Tetrahydro-8-(trifluoromethyl)-1H-pyrido[4,3-b]indole is a chemical compound with a complex and specific structure. It contains a tetrahydro-8-(trifluoromethyl) group attached to a 1H-pyrido[4,3-b]indole ring system. The presence of the trifluoromethyl group indicates that it likely has unique chemical and biological properties, as fluorine substituents are known to impact the reactivity and pharmacological potential of organic molecules. 2,3,4,5-Tetrahydro-8-(trifluoromethyl)-1H-pyrido[4,3-b]indole may have potential applications in various fields including medicine, agriculture, and materials science, but further research is needed to fully understand its properties and potential uses.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
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• 2923-56-0 4-(trifluoromethyl)phenylhydrazine hydrochloride 

Downstream Products

• 1095263-24-3 (1R,2R)-N-(1-cyanocyclopropyl)-2-{[8-(trifluoromethyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]carbonyl}cyclohexanecarboxamide 
• 1443130-12-8 ethyl 2-(2-benzoyl-8-(trifluoromethyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetate 

Relevant articles and documents

Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1 H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators

Cystic fibrosis (CF) is a life-threatening autosomal recessive disease, caused by mutations in the CF transmembrane conductance regulator (CFTR) chloride channel. CFTR modulators have been reported to address the basic defects associated with CF-causing mutations, partially restoring the CFTR function in terms of protein processing and/or channel gating. Small-molecule compounds, called potentiators, are known to ameliorate the gating defect. In this study, we describe the identification of the 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole core as a novel chemotype of potentiators. In-depth structure-activity relationship studies led to the discovery of enantiomerically pure 39 endowed with a good efficacy in rescuing the gating defect of F508del-and G551D-CFTR and a promising in vitro druglike profile. The in vivo characterization of γ-carboline 39 showed considerable exposure levels and good oral bioavailability, with detectable distribution to the lungs after oral administration to rats. Overall, these findings may represent an encouraging starting point to further expand this chemical class, adding a new chemotype to the existing classes of CFTR potentiators.

Novel Compound - 827

The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases, including cathepsins B, K, C, F, H, L, O, S, W and X. Of particular interest are diseases associated with Cathepsin K.