197368-49-3

Basic information

• Product Name: 5-(4-Aminophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8-one
• CAS NO: 197368-49-3
• Molecular Formula: C₁₆H₁₃N₃O₃
• Molecular Weight: 295.30031
• Mol File: 197368-49-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-(4-Aminophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Aminophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8-one(197368-49-3)
• EPA Substance Registry System: 5-(4-Aminophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8-one(197368-49-3)

Safety Data

• Hazardous Substances Data: 197368-49-3(Hazardous Substances Data)

Upstream product

• 197369-14-5 2-(4-nitrobenzoyl)-4,5-methylenedioxyphenylacetic acid methyl ester 
• 404-26-2 4-(trifluoroacetamido)benzoic acid 
• 326-59-0 benzo[1,3]dioxol-5-yl-acetic acid methyl ester 
• 194729-10-7 7,8-methylenedioxy-1-(4-nitrophenyl)-3,5-dihydro-2,3-benzodiazepin-4(4H)-one 
• 207238-95-7 {6-[4-(2,2,2-Trifluoro-acetylamino)-benzoyl]-benzo[1,3]dioxol-5-yl}-acetic acid methyl ester 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 
• 457-52-3 4-(2,2,2-trifluoro-acetylamino)-benzoyl chloride 

Relevant articles and documents

SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF

The invention relates to substituted 2,3-benzodiazepin-4-ones which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS

Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists

Novel 1-aryl-3,5-dihydro-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (12a-j) were prepared and their anticonvulsant effects were evaluated by using various models of experimental epilepsy. The seizures were evoked both by means of auditory stimulation

7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists

The synthesis and anticonvulsant activity of novel 7,8-methylenedioxy- 4H-2,3-benzodiazepin-4-ones 3a-e, structurally-related to GYKI 52466 1, a well-known noncompetitive AMPA-receptor antagonist, are reported. The new compounds possess marked anticonvuls